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Journal Articles

Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect

Yoshida, Fumiyo*; Matsumura, Akira*; Yamamoto, Tetsuya*; Kumada, Hiroaki; Nakai, Kei*

Cancer Letters, 215(1), p.61 - 67, 2004/11

 Times Cited Count:13 Percentile:22.46(Oncology)

Sodium borocaptate (BSH) is widely used for Boron Neutron Capture Therapy (BNCT) of brain tumors. However, the mechanism of uptake by the tumor remains unclear. We investigated the sulfhydryl moiety of this compound. Down regulation of glutathione (GSH) by buthionine sulfoximine (BSO) in cultured cells resulted in increase of BSH uptake (7.9 %-36.5 %) compared to control group and subsequently cytocidal effect of neutron irradiation also increased. The radiation damage by $$gamma$$-ray irradiation was suppressed by enhancement of BSH uptake. These findings suggested that modulation of GSH induce enhancement effect of B(n,$$alpha$$) reaction and protective effect of secondary $$gamma$$-ray in BNCT.

Journal Articles

Journal Articles

Changes in content and composition of sugar in molasses caused by gamma-irradiation

; *

J.Ferment.Technol., 58(4), p.363 - 366, 1980/00

no abstracts in English

Journal Articles

Analysis of the asymmetric 002 X-ray line profiles of $$gamma$$-irradiated polyethylene

; *

Japanese Journal of Applied Physics, 19(7), p.1241 - 1245, 1980/00

 Times Cited Count:11 Percentile:50.72(Physics, Applied)

no abstracts in English

Journal Articles

Crystallite size distribution and lattice distortions in highly $$gamma$$-irradiated linear polyethylene

; Kuriyama, Isamu

J.Mater.Sci., 14(7), p.1733 - 1743, 1979/00

 Times Cited Count:13

no abstracts in English

JAEA Reports

The Quantitative Analysis of Gas Evolved from High Polymer by $$gamma$$-Irradiation

Arakawa, Kazuo; Hayakawa, Naohiro; Kuriyama, Isamu

JAERI-M 7244, 29 Pages, 1977/09

JAERI-M-7244.pdf:0.81MB

no abstracts in English

Journal Articles

Improvement of the plateau characteristics of self-quenching GM counters by $$gamma$$-irradiation

Nuclear Instruments and Methods, 146, p.599 - 600, 1977/00

no abstracts in English

Journal Articles

Effects of cobalt-60 gamma-irradiation on browning compounds in wines

*; ; *; *

Hakko Kogaku Zasshi, 53(2), p.84 - 91, 1975/02

no abstracts in English

Journal Articles

Carbon sources and formation mechanisms of organic iodides in nitric acid solutions

Saeki, Masakatsu; *; Tachikawa, Enzo

Int.J.Appl.Radiat.Isot., 25(9), p.407 - 414, 1974/09

 Times Cited Count:8

no abstracts in English

Journal Articles

Neutron and $$gamma$$-irradiation of propionamide

Tachikawa, Enzo; Tsuchihashi, Genichi

Bulletin of the Chemical Society of Japan, 34(6), p.770 - 774, 1961/00

 Times Cited Count:3

no abstracts in English

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